Steatotic liver disease - Causes & Treatment
Steatotic liver disease refers to disorders characterized by abnormal lipid accumulation in the liver (liver or hepatic steatosis). Steatotic liver disease includes what was previously known as non-alcoholic fatty liver disease (NAFLD), but is now referred to as metabolic dysfunction-associated steatotic liver disease. Steatotic liver disease also includes alcohol-related liver disease (ALD), MetALD, a new categorization for the overlap between MASLD and ALD, as well as unusual causes of liver steatosis. Steatotic liver disease affects around 30% of the global population and is mostly caused by obesity, type 2 diabetes, and alcohol consumption; however, only a small fraction of those with steatotic liver disease develop cirrhosis. The presence and advancement of liver fibrosis caused by hepatic inflammation is the most reliable predictor of liver death across the whole range of steatotic liver disorders. A combination of recent advances in widely available biomarkers ...